During night skincare routine, after washing your face, spread proper amount evenly and massage until absorbed. DO NOT USE reedle shot 100, 300, and 700 at the same time. DO NOT USE with beauty/skincare devices that produce high temperatures or light, such as LED masks. AVOID USE immediately after dermatological procedures, such as laser treatments or injections, when the skin is irritated. Allow up to 2 weeks for the skin to fully heal before using Reedle Shot.